2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W411236
    Methyl 3-hydroxynonanoate 83968-06-3 98%
    Methyl 3-hydroxynonanoate is an ester product.
    Methyl 3-hydroxynonanoate
  • HY-W414457
    7α,27-Dihydroxy-4-cholesten-3-one 192187-67-0 98%
    7α,27-Dihydroxy-4-cholesten-3-one is an oxysterol.
    7α,27-Dihydroxy-4-cholesten-3-one
  • HY-W414519
    1-Desoxymethylsphingosine (m17:1) 1246303-16-1 98%
    1-Desoxymethylsphingosine (m17:1) is a sphingosine.
    1-Desoxymethylsphingosine (m17:1)
  • HY-W414803
    VU0155056 1130067-18-3 98%
    VU0155056 is a cell-permeable phospholipase D inhibitor.
    VU0155056
  • HY-W415007
    Isopropyl stearate 112-10-7 98.0%
    Isopropyl stearate (Stearic acid,isopropyl ester) is an ester product.
    Isopropyl stearate
  • HY-W415060
    Myristylmyristate 3234-85-3 98%
    Myristylmyristate (Tetradecyl tetradecanoate) is an ester product.
    Myristylmyristate
  • HY-W415231
    Tyrosine ethyl ester 34081-17-9 98%
    Tyrosine ethyl ester exhibits antioxidant activity.
    Tyrosine ethyl ester
  • HY-W416440
    Esmolol acid hydrochloride 83356-60-9 98%
    Esmolol acid (ASL-8123) hydrochloride is a weak β-adrenergic receptor antagonist. Esmolol acid hydrochloride inhibits the heart rate and diastolic blood pressure response induced by Isoproterenol (HY-B0468) in a dose-dependent manner and can be used in studies of renal failure.
    Esmolol acid hydrochloride
  • HY-W423573
    N,S-Diacetylcysteine methyl ester 19547-88-7 98%
    N,S-Diacetylcysteine ​​methyl ester is a cysteine ​​derivative that can increase the levels of intracellular cysteine ​​and glutathione. N,S-Diacetylcysteine ​​methyl ester is hydrolyzed by intracellular esterase to release cysteine, thereby promoting the synthesis of glutathione. Due to its acetylation properties, N,S-Diacetylcysteine ​​methyl ester has better cell membrane permeability and can enter the cell more effectively. N,S-Diacetylcysteine ​​methyl ester can be used to study the intracellular cysteine ​​and glutathione (GSH) transport system.
    N,S-Diacetylcysteine methyl ester
  • HY-W436495
    6,15-Diketo-13,14-dihydro prostaglandin F1α 63983-53-9 98%
    6,15-Diketo-13,14-dihydro prostaglandin F1α (6,15-Diketo-13,14-dihydro-PGF1α) is a metabolite of prostacyclin (PGI2). 6,15-Diketo-13,14-dihydro prostaglandin F1α enhances intracellular cAMP and cholesterol metabolism in bovine arterial smooth muscle cells.
    6,15-Diketo-13,14-dihydro prostaglandin F1α
  • HY-W438351
    1,3-Dibenzyl-5-fluorouracil 75500-02-6 98%
    1,3-Dibenzyl-5-fluorouracil is a chemical inhibitor of osteoclastogenesis. 1,3-Dibenzyl-5-fluorouracil inhibits the expression of osteoclast markers by downregulating the receptor activator of NF-κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) signaling pathways. 1,3-Dibenzyl-5-fluorouracil can be used in the study of metabolic bone diseases.
    1,3-Dibenzyl-5-fluorouracil
  • HY-W439487
    7,9-Dimethylguanine 524-35-6 98%
    7,9-Dimethylguanine is a modified nucleotide base that is a product of RNA degradation. The level of 7,9-Dimethylguanine in urine and serum can be used as a scoring indicator for the severity of alcoholic liver disease (ALD).
    7,9-Dimethylguanine
  • HY-W482407
    1,2-O-Dihexadecyl-sn-glycerol 67337-03-5 98.03%
    1,2-O-Dihexadecyl-sn-glycerol ((S)-2,3-Bis(hexadecyloxy)propan-1-ol) is a saturated dialkyl glyceryl ether with hexadecyl groups at the sn-1 and sn-2 positions that mimics the structure of diacylglycerol.
    1,2-O-Dihexadecyl-sn-glycerol
  • HY-W497648
    Undecyl acetate 1731-81-3 98%
    Undecyl acetate (1-Undecanol, 1-acetate) is an ester product.
    Undecyl acetate
  • HY-W504717
    2,3-Dihydroxypropyl tridecanoate 71958-74-2 98%
    2,3-Dihydroxypropyl tridecanoate is an acylglycerol.
    2,3-Dihydroxypropyl tridecanoate
  • HY-W505108
    2,3-Dihydroxypropyl pentadecanoate 62927-08-6 99.83%
    2,3-Dihydroxypropyl pentadecanoate is a monoacylglycerol that is found in wheat bran extracts. 2,3-Dihydroxypropyl pentadecanoate levels are increased in a HepaRG cell-based model of hepatic steatosis induced by BSA-conjugated palmitate.
    2,3-Dihydroxypropyl pentadecanoate
  • HY-W517092
    1,2,3,4,7,8,9-Heptachlorodibenzofuran 55673-89-7 98%
    1,2,3,4,7,8,9-Heptachlorodibenzofuran (1,2,3,4,7,8,9-HpCDF) is a compound that induces the expression of CYP1A1 and CYP1B1 genes in human peripheral blood lymphocytes, while also promoting the expression of the aryl hydrocarbon receptor repressor (AhRR). 1,2,3,4,7,8,9-Heptachlorodibenzofuran can increase ethoxyresorufin-O-deethylase (EROD) activity in isolated human peripheral blood lymphocytes in a concentration-dependent manner, which serves as a marker of CYP1A1 activity. Furthermore, 1,2,3,4,7,8,9-Heptachlorodibenzofuran exhibits immunosuppressive effects by reducing the number of splenic plaque-forming cells in mice and increasing aryl hydrocarbon hydroxylase (AHH) activity in liver microsomes of mice injected with sheep red blood cells. 1,2,3,4,7,8,9-Heptachlorodibenzofuran can be used in research in the fields of immunology, metabolic diseases, and environmental toxicology.
    1,2,3,4,7,8,9-Heptachlorodibenzofuran
  • HY-W540864
    Pentacontane 6596-40-3 98%
    Pentacontane is an ester product.
    Pentacontane
  • HY-W540905
    Tetratetracontane 7098-22-8 98%
    Tetratetracontane is an ester product.
    Tetratetracontane
  • HY-W550311
    Stearyl laurate 3234-84-2 98%
    Stearyl laurate is an ester product.
    Stearyl laurate
Cat. No. Product Name / Synonyms Application Reactivity